Endocrine Abstracts

Background: Hypercalciuria is a relevant complication in patients with treated hypoparathyroidism. Hypercalciuria is usually estimated by 24 h urinary calcium excretion (24 hUCa). In contrast, in pediatric endocrinology the calcium-creatinine-ratio (CaCrR) is more often used due to feasibility. This study aims to compare these two approaches in adult patients with hypoparathyroidism.Methods: In 181 systematically evaluated patients with primary hypoparat...

Background: Confirmation of primary aldosteronism (PA) with the saline infusion test (SIT) requires accurate measurements of plasma aldosterone, best achieved by mass spectrometry. Performance of the test and appropriate cut-offs remain inadequately defined.Design and methods: This prospective multicenter cohort study involved 451 patients with suspected PA who underwent a seated SIT. Among these, there were 90 and 76 in whom PA was respectively confirmed and excluded based on...

Adrenal tumours are frequently detected by conventional cross-sectional imaging, which, however, has limited specificity in identifying the most prevalent tumour type, benign, non-functional adrenocortical adenomas (ACA) not requiring surgery. We assessed the diagnostic accuracy of adrenal molecular imaging with [18F]Fluorodeoxyglucose-positron emission tomography (FDG-PET) and [123I]Iodometomidate-single photon emission tomography (IMTO-SPECT). We perfor...